کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2945212 1577125 2013 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
New Trial Designs and Potential Therapies for Pulmonary Artery Hypertension
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
New Trial Designs and Potential Therapies for Pulmonary Artery Hypertension
چکیده انگلیسی

A greater understanding of the epidemiology, pathogenesis, and pathophysiology of pulmonary artery hypertension (PAH) has led to significant advances, but the disease remains fatal. Treatment options are neither universally available nor always effective, underscoring the need for development of novel therapies and therapeutic strategies. Clinical trials to date have provided evidence of efficacy, but were limited in evaluating the scope and duration of treatment effects. Numerous potential targets in varied stages of drug development exist, in addition to novel uses of familiar therapies. The pursuit of gene and cell-based therapy continues, and device use to help acute deterioration and chronic management is emerging. This rapid surge of drug development has led to multicenter pivotal clinical trials and has resulted in novel ethical and global clinical trial concerns. This paper will provide an overview of the opportunities and challenges that await the development of novel treatments for PAH.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the American College of Cardiology - Volume 62, Issue 25, Supplement, 24 December 2013, Pages D82–D91
نویسندگان
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