کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2948968 1577295 2010 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Novel Baroreflex Activation Therapy in Resistant Hypertension : Results of a European Multi-Center Feasibility Study
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Novel Baroreflex Activation Therapy in Resistant Hypertension : Results of a European Multi-Center Feasibility Study
چکیده انگلیسی

ObjectivesThis study assessed the safety and efficacy of a novel implantable device therapy in resistant hypertension patients.BackgroundDespite the availability of potent antihypertensive drugs, a substantial proportion of patients remain hypertensive. A new implantable device (Rheos system, CVRx, Inc., Minneapolis, Minnesota) that activates the carotid baroreflex may help these patients.MethodsForty-five subjects with systolic blood pressure ≥160 mm Hg or diastolic ≥90 mm Hg despite at least 3 antihypertensive drugs were enrolled in a prospective, nonrandomized feasibility study to assess whether Rheos therapy could safely lower blood pressure. Subjects were followed up for as long as 2 years. An external programmer was used to optimize and individualize efficacy.ResultsBaseline mean blood pressure was 179/105 mm Hg and heart rate was 80 beats/min, with a median of 5 antihypertensive drugs. After 3 months of device therapy, mean blood pressure was reduced by 21/12 mm Hg. This result was sustained in 17 subjects who completed 2 years of follow-up, with a mean reduction of 33/22 mm Hg. The device exhibited a favorable safety profile.ConclusionsThe Rheos device sustainably reduces blood pressure in resistant hypertensive subjects with multiple comorbidities receiving numerous medications. This unique therapy offers a safe individualized treatment option for these high-risk subjects. This novel approach holds promise for patients with resistant hypertension and is currently under evaluation in a prospective, placebo-controlled clinical trial.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the American College of Cardiology - Volume 56, Issue 15, 5 October 2010, Pages 1254–1258
نویسندگان
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