کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2949495 | 1577375 | 2009 | 7 صفحه PDF | دانلود رایگان |
ObjectivesThis study sought to evaluate the natural history of occult cardiac dysfunction in Duchenne muscular dystrophy (DMD).BackgroundDuchenne muscular dystrophy is characterized by progressive cardiac dysfunction and myocardial fibrosis late in the disease process. We hypothesized that left ventricular myocardial peak circumferential strain (εcc) would decrease in DMD before global systolic functional abnormalities regardless of age or ventricular ejection fraction (EF).MethodsWe evaluated cardiac magnetic resonance image (MRI) data from 70 DMD patients and 16 aged-matched control subjects. Standard imaging data included steady-state free precession short-axis cine stack images, cine myocardial tagged images, and myocardial delayed enhancement (MDE) (an indicator of myocardial fibrosis) sequences. Analysis was performed with QMASS (Medis Medical Imaging Systems, Leiden, the Netherlands) and HARP (Diagnosoft, Palo Alto, California) software. The DMD patient data were subdivided by age (<10 or >10 years), EF (>55% or <55%), and the presence or absence of MDE.ResultsThe DMD patients with normal EF had reduced εccat an early age (<10 years) compared with control subjects (p < 0.01). The DMD patients age >10 years with normal EF had further decline in εcccompared with younger DMD patients (p < 0.01). There was further decline in εccwith age in patients with reduced EF (p < 0.01) without MDE. The oldest patients, with both reduced EF and positive MDE, exhibited the lowest εcc. None of the patients had ventricular hypertrophy.ConclusionsMyocardial strain abnormalities are prevalent in young DMD patients despite normal EF, and these strain values continue to decline with advancing age. Strain analysis in combination with standard MRI and MDE imaging provides a means to stratify DMD cardiomyopathy.
Journal: Journal of the American College of Cardiology - Volume 53, Issue 14, 7 April 2009, Pages 1204–1210