کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2953309 1577427 2008 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Reversibility of Cardiac Abnormalities in Morbidly Obese Adolescents
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Reversibility of Cardiac Abnormalities in Morbidly Obese Adolescents
چکیده انگلیسی

ObjectivesThe purpose of this study was to evaluate changes in cardiac geometry, systolic and diastolic function before and after weight loss in morbidly obese adolescents.BackgroundCardiac abnormalities are present in morbidly obese adolescents; however, it is unclear if they are reversible with weight loss.MethodsData from 38 adolescents (13 to 19 years; 29 females, 9 males, 33 Caucasians, 5 African Americans) were evaluated before and after bariatric surgery. Left ventricular mass (LVM), left ventricular (LV) geometry, systolic and diastolic function were assessed by echocardiography. Mean follow up was 10 ± 3 months.ResultsWeight and body mass index decreased post-operatively (mean weight loss 59 ± 15 kg, pre-operative body mass index 60 ± 9 kg/m2 vs. follow-up 40 ± 8 kg/m2, p < 0.0001). Change in LVM index (54 ± 13 g/m2.7 to 42 ± 10 g/m2.7, p < 0.0001) correlated with weight loss (r = 0.41, p = 0.01). Prevalence of concentric left ventricular hypertrophy (LVH) improved from 28% at pre-operative to only 3% at follow up (p = 0.007), and normal LV geometry improved from 36% to 79% at follow up (p = 0.009). Diastolic function also improved (mitral E/Ea lateral 7.7 ± 2.3 at pre-operative vs. 6.3 ± 1.6 at post-operative, p = 0.003). In addition, rate-pressure product improved suggesting decreased cardiac workload (p < 0.001).ConclusionsElevated LVM index, concentric LVH, altered diastolic function, and cardiac workload significantly improve following surgically induced weight loss in morbidly obese adolescents. Large weight loss due to bariatric surgery improves predictors of future cardiovascular morbidity in these young people.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the American College of Cardiology - Volume 51, Issue 14, 8 April 2008, Pages 1342–1348
نویسندگان
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