کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2953864 1577512 2006 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Biventricular Versus Conventional Right Ventricular Stimulation for Patients With Standard Pacing Indication and Left Ventricular Dysfunction: The Homburg Biventricular Pacing Evaluation (HOBIPACE)
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Biventricular Versus Conventional Right Ventricular Stimulation for Patients With Standard Pacing Indication and Left Ventricular Dysfunction: The Homburg Biventricular Pacing Evaluation (HOBIPACE)
چکیده انگلیسی

ObjectivesThe Homburg Biventricular Pacing Evaluation (HOBIPACE) is the first randomized controlled study that compares the biventricular (BV) pacing approach with conventional right ventricular (RV) pacing in patients with left ventricular (LV) dysfunction and a standard indication for antibradycardia pacing in the ventricle.BackgroundIn patients with LV dysfunction and atrioventricular block, conventional RV pacing may yield a detrimental effect on LV function.MethodsThirty patients with standard indication for permanent ventricular pacing and LV dysfunction defined by an LV end-diastolic diameter ≥60 mm and an ejection fraction ≤40% were included. Using a prospective, randomized crossover design, three months of RV pacing were compared with three months of BV pacing with regard to LV function, N-terminal pro-B-type natriuretic peptide (NT-proBNP) serum concentration, exercise capacity, and quality of life.ResultsWhen compared with RV pacing, BV stimulation reduced LV end-diastolic (−9.0%, p = 0.022) and end-systolic volumes (−16.9%, p < 0.001), NT-proBNP level (−31.0%, p < 0.002), and the Minnesota Living with Heart Failure score (−18.9%, p = 0.01). Left ventricular ejection fraction (+22.1%), peak oxygen consumption (+12.0%), oxygen uptake at the ventilatory threshold (+12.5%), and peak circulatory power (+21.0%) were higher (p < 0.0002) with BV pacing. The benefit of BV over RV pacing was similar for patients with (n = 9) and without (n = 21) atrial fibrillation. Right ventricular function was not affected by BV pacing.ConclusionsIn patients with LV dysfunction who need permanent ventricular pacing support, BV stimulation is superior to conventional RV pacing with regard to LV function, quality of life, and maximal as well as submaximal exercise capacity.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the American College of Cardiology - Volume 47, Issue 10, 16 May 2006, Pages 1927–1937
نویسندگان
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