کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2956936 1578066 2012 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Microparticles in cardiovascular disease pathophysiology and outcomes
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی سیستم های درون ریز و اتونومیک
پیش نمایش صفحه اول مقاله
Microparticles in cardiovascular disease pathophysiology and outcomes
چکیده انگلیسی

Microparticles (MPs) are vesicles less than one micron in diameter shed from the plasma membranes of cells that are injured, activated, or undergoing apoptosis. MPs are shed from several types of cells, and the cells of origin can be identified using combinations of antigenic markers. Platelet MPs, which play a role in coagulation and atherogenesis, are the most abundant MPs in the circulation. In vivo studies have demonstrated platelet MP levels to be higher in patients who have had acute ischemic stroke and in patients with greater degrees of retinopathy. In addition, platelet MP levels have been shown to be higher in patients with severe hypertension and in those with increased coronary heart disease risk. Endothelial MPs affect vascular tone, permeability, and hemostasis. Higher endothelial MP levels have been shown to correlate with loss of flow-mediated dilation, arterial stiffness, and severe hypertension. Most compelling are recent cohort studies that have shown endothelial MP levels to be independent predictors of cardiovascular disease events. Although more research is needed, studies suggest that MPs may have clinical applications including utility as biomarkers, use in improving cardiovascular disease risk prediction, and as potential targets of therapy.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the American Society of Hypertension - Volume 6, Issue 4, July–August 2012, Pages 243–252
نویسندگان
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