کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2956958 1578068 2012 15 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Cellular biomarkers of endothelial health: microparticles, endothelial progenitor cells, and circulating endothelial cells
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی سیستم های درون ریز و اتونومیک
پیش نمایش صفحه اول مقاله
Cellular biomarkers of endothelial health: microparticles, endothelial progenitor cells, and circulating endothelial cells
چکیده انگلیسی

Endothelial dysfunction, the shift from a healthy endothelium to a damaged pro-coagulative, pro-inflammatory, and pro-vasoconstrictive phenotype, is an early event in many chronic diseases that frequently precedes cardiovascular complications. Functional assessment of the endothelium can identify endothelial damage and predict cardiovascular risk; however, this assessment provides little information as to the mechanisms underlying development of endothelial dysfunction. Changes in plasma asymmetric dimethyl arginine levels, markers of lipid peroxidation, circulating levels of inflammatory mediators, indices of coagulation and cellular surrogates such as microparticles, circulating endothelial cells, and endothelial progenitor cells may reflect alterations in endothelial status and as such have been defined as “biomarkers” of endothelial function. Biomarkers may be chemical or cellular. This review examines some markers of endothelial dysfunction, with a particular focus on cellular biomarkers of endothelial dysfunction and their diagnostic potential.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the American Society of Hypertension - Volume 6, Issue 2, March–April 2012, Pages 85–99
نویسندگان
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