Drug-induced Brugada syndrome

• A variety of drugs can unmask or induce phenotypes and arrhythmic manifestations of Brugada syndrome.
• We summarized drugs which can induce Brugada phenotype.
• We focused on drug-induced BrS phenotypes, prevalence, and underlying mechanisms.

Brugada syndrome (BrS) is an inherited cardiac disorder that is associated with an electrocardiogram pattern of ST segment elevation on right precordial leads and a high incidence of sudden death. Diagnosis requires documentation of a coved-type ST segment that occurs spontaneously or in the presence of a class IA or IC antiarrhythmic agent. A wide variety of other drugs, including antianginals, antidepressants, antipsychotics, and antihistamines, have been reported to unmask or induce the electrocardiographic and arrhythmic manifestations of BrS. This review focuses on drug-induced BrS phenotypes, prevalence, and underlying mechanisms.