کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2958290 1178285 2016 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The Added Value of Exercise Variables in Heart Failure Prognosis
ترجمه فارسی عنوان
ارزش افزوده متغیرهای ورزشی در پیش بینی بیماری نارسایی قلبی
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
چکیده انگلیسی


• This study shows that peak VO2, OUES, and VE/VCO2 slope are independent predictors of HF prognosis when analyzed in association with recognized clinical predictors.
• Peak VO2, OUES, and VE/VCO2 slope add prognostic value when included with relevant clinical predictors of HF.
• These exercise variables are equivalent in predicting prognosis when adjusted for clinical prognostic factors.
• During submaximal exercise, peak VO2 yielded predictive results equivalent to other submaximal exercise variables.

IntroductionDiminished exercise capacity is a key symptom in heart failure (HF). Exercise predictors (peak VO2, VE/VCO2 slope, and oxygen uptake efficiency slope [OUES]) are prognostic markers but studied in isolation. We evaluated if these exercise variables offer additional prognostic value to clinical predictors in HF.Methods and ResultsThis was a single-institution retrospective cohort study of 517 consecutive HF patients. We used Cox proportional hazards modeling to determine the additional prognostic value of exercise variables on mortality, HF hospital admissions, and a composite outcome of ventricular assistance device (VAD) implantation, heart transplantation (HT), and death. During a mean follow-up of 2.7 years, 52 deaths, 47 HTs, and 19 VAD implantations occurred. After adjusting for age, New York Heart Association functional class, ejection fraction, body mass index, creatinine, and B-type natriuretic peptide, peak VO2 (hazard ratio [HR] 0.91, 95% confidence interval [CI] 0.85–0.96), OUES (HR 0.92, 95% CI 0.87–0.97), and VE/VCO2 (HR 1.03, 95% CI 1.01–1.05) were independent predictors of the composite outcome. Similar discriminatory capacity existed between the exercise variables (c-statistics 0.77, 0.78, and 0.78, respectively). Only VE/VCO2 was an independent predictor of admissions (HR 1.04, 95% CI 1.01–1.07), and only peak VO2 was an independent predictor of mortality (HR 0.90, 95% CI 0.84–0.98).ConclusionsPeak VO2, OUES, and VE/VCO2 are independent predictors of HF prognosis over recognized clinical variables. However, no single exercise variable was superior.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Cardiac Failure - Volume 22, Issue 7, July 2016, Pages 492–497
نویسندگان
, , , , , , ,