کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2958457 1178290 2016 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Prediction of Acute Response to Cardiac Resynchronization Therapy by Means of the Misbalance in Regional Left Ventricular Myocardial Work
ترجمه فارسی عنوان
پیش بینی پاسخ حاد به درمان مجدد قلب با استفاده از ناسازگاری در کارآزمایی های قلبی بطن چپ منطقه ای
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
چکیده انگلیسی


• Segmental myocardial work can be derived from regional strain rate and LV pressure.
• The septal contribution to LV work varies widely in CRT candidates with LBBB.
• Misbalance in myocardial work determines acute pump function improvement by means of CRT.

BackgroundPatients with left ventricular (LV) dyssynchrony have a marked misbalance in LV myocardial work distribution, with wasted work in the septum and increased work in the lateral wall. We hypothesized that a low septum-to-lateral wall (SL) myocardial work ratio at baseline predicts acute LV pump function improvement during cardiac resynchronization therapy (CRT).Methods and ResultsTwenty patients (age 65 ± 10 y, 15 men) underwent cardiac magnetic resonance (CMR) tagging for regional LV circumferential strain assessment and invasive pressure-volume loop assessment at baseline and during biventricular pacing. Segmental work at baseline was calculated from regional strain rate and LV pressure. Subsequently, the SL work ratio was calculated and related to acute pump function (stroke work [SW]) improvement during CRT. During biventricular pacing, SW increased by 33% (P < .001). SL work ratio at baseline was found to be significantly related to SW improvement by means of CRT (R = −0.54; P = .015). Moreover, it proved to be the only marker that was significantly related to acute response to CRT, whereas QRS duration and other measures of dyssynchrony or dyscoordination were not.ConclusionsThe contribution of the septum to LV work varies widely in CRT candidates with left bundle branch block. The lower the septal contribution to myocardial work at baseline, the higher the acute pump function improvement that can be achieved during CRT.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Cardiac Failure - Volume 22, Issue 2, February 2016, Pages 133–142
نویسندگان
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