کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2958899 1178301 2015 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Should Cardiac Resynchronization Therapy Be a Rescue Therapy for Inotrope-Dependent Patients With Advanced Heart Failure?
ترجمه فارسی عنوان
آیا درمان مجدد قلب باید یک درمان نجات برای بیماران مبتلا به نارسایی با نارسایی قلب پیشرفته باشد؟
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
چکیده انگلیسی


• Patients dependent on inotropes sometimes receive CRT-D as the “last resort.”
• CRT-D does not improve survival in patients dependent on inotropes without LVAD.
• LVAD therapy should be considered instead of CRT-D in such advanced patients.

BackgroundAlthough the “off-label usage” of cardiac resynchronization therapy with defibrillator (CRT-D) has spread recently in advanced heart failure (HF) patients in the real-world practice, its clinical effect remained uncertain.Methods and ResultsA total of 84 in-hospital <65-year old patients with advanced HF undergoing CRT-D were enrolled. Seventeen patients (20%) had been dependent on inotropes at the time of CRT-D implantation, and 17 suffered cardiac death within a year. Both inotrope dependence and elevated plasma levels of B-type natriuretic peptide (BNP) (>690 pg/mL) at the time of CRT-D implantation were independent predictors of cardiac death within a year by Cox regression analyses (P < 0.05 for both). These 2 parameters could significantly stratify 1-year ventricular assist device (VAD)-free survival: inotrope-free low (1) or high BNP (2), or inotrope-dependent low (3) or high BNP groups (4) (98, 77, 57, and 17%, respectively, P < 0.001). In contrast, there were no significant differences in actual 1-year survival among the four groups.ConclusionPatients dependent on inotropes sometimes receive CRT-D therapy as the last treatment resort in clinical practice, but LVAD implantation should be considered instead of CRT-D in advanced HF patients because of their poor prognosis with CRT-D therapy.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Cardiac Failure - Volume 21, Issue 6, June 2015, Pages 535–538
نویسندگان
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