کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2959937 1178338 2012 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effect of Adaptive Servoventilation on Muscle Sympathetic Nerve Activity in Patients With Chronic Heart Failure and Central Sleep Apnea
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Effect of Adaptive Servoventilation on Muscle Sympathetic Nerve Activity in Patients With Chronic Heart Failure and Central Sleep Apnea
چکیده انگلیسی

BackgroundAdaptive servoventilation (ASV) improves cardiac function and sympathetic nerve activity in patients with heart failure (HF). However, the mechanisms underlying these improvements remain obscure.Methods and ResultsWe compared muscle sympathetic nerve activity (MSNA) and cardiorespiratory polygraphy and echocardiography findings at baseline and at 3.5 ± 0.8 months’ follow-up in 32 patients with HF (New York Heart Association functional class II or III; ejection fraction <45%) and central sleep apnea (CSA; apnea-hypopnea index [AHI] ≥15/h) who consented (n = 20; ASV group) or declined (n = 12; non-ASV group) to undergo ASV treatment. Compliance with ASV and changes in AHI were determined from data collected by integral counters in devices and from cardiorespiratory polygraphic findings, respectively. Ejection fraction and MSNA significantly changed in the ASV (both P < .001) but not the non-ASV group. Although changes in AHI and MSNA correlated, the average use of ASV did not. In contrast, changes in AHI and the average use of ASV were independent predictors of changes in ejection fraction (both P < .01).ConclusionsASV decreases MSNA and improves cardiac function in association with suppression of CSA in patients with HF.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Cardiac Failure - Volume 18, Issue 10, October 2012, Pages 769–775
نویسندگان
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