کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2961262 1178390 2011 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Association of Resistin With Heart Failure and Mortality in Patients With Stable Coronary Heart Disease: Data From the Heart and Soul Study
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Association of Resistin With Heart Failure and Mortality in Patients With Stable Coronary Heart Disease: Data From the Heart and Soul Study
چکیده انگلیسی

BackgroundResistin is a pro-inflammatory signaling molecule that is thought to contribute to atherosclerosis. We sought to evaluate whether resistin is predictive of worse cardiovascular outcomes among ambulatory patients with stable coronary heart disease (CHD).Methods and ResultsWe measured baseline serum resistin in 980 participants with documented CHD. After a mean follow-up of 6.1 (range, 0.1 to 9.0) years, 358 (36.5%) were hospitalized for myocardial infarction or heart failure or had died. As compared with participants who had resistin levels in the lowest quartile, those with resistin levels in the highest quartile were at an increased risk of heart failure (hazard ratio [HR], 2.06; 95% confidence interval [CI], 1.26–3.39) and death (HR, 1.56; 95% CI, 1.11–2.18), adjusted for age, sex, and race. Further adjustments for obesity, hypertension, insulin resistance, dyslipidemia, and renal dysfunction eliminated these associations. Resistin levels were not associated with an increased risk of non-fatal myocardial infarction (unadjusted HR, 1.18; 95% CI, 0.68-2.05).ConclusionsElevated serum resistin is associated with higher rates of mortality and hospitalization for heart failure. However, this appears to be explained by the association of resistin with traditional measures of cardiovascular risk. Thus, serum resistin does not add prognostic information among high-risk persons with established CHD.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Cardiac Failure - Volume 17, Issue 1, January 2011, Pages 24–30
نویسندگان
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