کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2962944 1178515 2015 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Arterial stiffness in patients after Kawasaki disease without coronary artery involvement: Assessment by performing brachial ankle pulse wave velocity and cardio-ankle vascular index
ترجمه فارسی عنوان
سختی شریان در بیماران پس از بیماری کاوازاکی بدون دخالت عروق کرونر: ارزیابی با استفاده از سرعت موج پالس مفصل مچ پا و شاخص عروق قلبی-مچ دست
کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
چکیده انگلیسی

BackgroundIt remains unclear whether systemic arterial beds other than the coronary arteries are truly healthy in patients without coronary artery lesions (CAL) after Kawasaki disease (KD). We tested the hypothesis that patients with KD without echocardiographic evidence of CAL during the acute phase of the disease have abnormal mechanical properties in systemic arteries later.Methods and resultsWe studied 201 consecutive patients with KD (age 2–23 years, mean 10 ± 4 years; 109 male, 92 female) without CAL during the acute phase. Data were compared with those in 129 control subjects (age 2–25 years, mean 10 ± 4 years; 73 male, 56 female; control group). We examined arterial stiffness by using the brachial–ankle pulse wave velocity (baPWV) and the cardio-ankle vascular index (CAVI). The baPWV in the KD group was significantly higher than that in the control group (913 ± 121 cm/s vs. 886 ± 135 cm/s, p = 0.04). In contrast, there was no significant difference in CAVI (4.0 ± 1.0 vs. 4.2 ± 1.0, p = 0.9) between the two groups. Multivariate analysis indicated a highly significant difference in baPWV (higher baPWV in patients with KD than in controls, p = 0.004), after controlling for age, gender, body height and weight, and systolic and diastolic blood pressure, but no difference in CAVI between the groups.ConclusionYears after KD occurs in patients without apparent CAL during the acute phase, there is a small but significant change in systemic arterial properties, characterized by increased wall stiffness. The clinical importance of these findings must be clarified by performing long-term follow-up studies.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Cardiology - Volume 66, Issue 2, August 2015, Pages 130–134
نویسندگان
, , , , , , , , ,