کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2962980 1178518 2015 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Impact of persistent smoking on long-term outcomes in patients with nonvalvular atrial fibrillation
ترجمه فارسی عنوان
تاثیر سیگار کشیدن پایدار بر نتایج بلندمدت در بیماران مبتلا به فیبریلاسیون دهلیزی غیر واگیردار
کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
چکیده انگلیسی

BackgroundAlthough smoking is a risk factor for cardiovascular diseases, little is known about the impact of smoking on long-term outcomes in patients with atrial fibrillation (AF).MethodsIn 426 consecutive patients with nonvalvular AF (mean age, 66 years; 307 men; mean follow-up, 5.8 ± 3.2 years), clinical variables including smoking status, CHADS2, and CHA2DS2-VASc score, incidences of cardiovascular events (stroke, myocardial infarction, or admission for heart failure), bleeding, and mortality were determined.ResultsIncidences of intracranial bleeding (0.7% vs 0.1%/year, p < 0.01), all-cause mortality (4.9% vs 2.6%/year, p < 0.01), and death from stroke (0.8% vs 0.2%/year, p < 0.05) were higher in patients with history of smoking than in those without it. Incidence of intracranial bleeding was significantly higher in persistent smokers than in non-persistent smokers (1.2% vs 0.2%/year, p < 0.01). History of smoking predicted all-cause mortality [hazard ratio (HR), 2.7; 95% confidence interval (CI), 1.7–4.5; p < 0.01] and death from stroke (HR 4.7; 95% CI 1.0–22.3; p < 0.05) independent of age, antithrombotic treatment, CHADS2, and CHA2DS2-VASc score. Persistent smoking predicted intracranial bleeding (HR 4.4; 95% CI 1.1–17.6; p < 0.05) independent of age and antithrombotic treatment.ConclusionsSmoking status, independent of age, antithrombotic treatment, and clinical risk factors, predicted long-term adverse outcomes including bleeding events in patients with nonvalvular AF. There might be an obvious impact of persistent smoking on intracranial bleeding.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Cardiology - Volume 65, Issue 5, May 2015, Pages 429–433
نویسندگان
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