Medial necrosis due to sirolimus-eluting stent implantation in human coronary artery

SummaryWe report an autopsy case showing medial necrosis at the segment of sirolimus-eluting stent implantation. These findings indicate that cytotoxic effects of sirolimus can induce late-acquired incomplete stent apposition and/or aneurysmal changes after stenting in human coronary arteries.