کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2963514 1178564 2012 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Impact of diabetes mellitus on outcomes in Japanese patients undergoing coronary artery bypass grafting
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Impact of diabetes mellitus on outcomes in Japanese patients undergoing coronary artery bypass grafting
چکیده انگلیسی

SummaryBackground and purposeThere have been no large-scale studies on the impact of diabetes mellitus (DM) on outcomes in Japanese patients undergoing coronary artery bypass grafting (CABG).Methods and subjectsA multi-institutional retrospective cohort study was conducted in 14 Japanese centers. All adult patients who underwent isolated CABG from 2007 to 2008 were included (n = 1522, mean age: 68.5 years). The definitions of DM were all patients admitted with diagnosis of DM and preoperative glycated hemoglobin (Hb) A1c ≥ 6.5%. Univariate and multivariate analyses were performed to identify the risk of morbidity and mortality.ResultsThere were 849 DM and 572 non-DM patients. Preoperative mean HbA1c were 7.1% in the DM group and 5.7% in the non-DM group (p < 0.0001). Preoperative, intraoperative, and 3-day average postoperative blood glucose (BG) were 146 mg/dl, 172 mg/dl, and 168 mg/dl in the DM group, and 103 mg/dl, 140 mg/dl, and 136 mg/dl in the non-DM group (all p < 0.0001). Although there were no significant differences in postoperative cardiovascular events, the incidence of infection was significantly higher in the DM group than in the non-DM group (9.2% vs 6.1%, p = 0.036) on the univariate analysis. The all-cause death was also relatively higher in the DM group than in the non-DM group (2.1% vs 1.1%, p = 0.12), and this was likely related to infection.ConclusionDM patients had worse perioperative BG control, higher incidence of infection, and higher mortality than non-DM patients. These results indicate that perioperative BG control guidelines should be standardized to obtain better surgical outcomes in Japanese DM patients.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Cardiology - Volume 59, Issue 3, May 2012, Pages 275–284
نویسندگان
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