کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2963544 1178565 2009 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Longitudinal analysis of the depressive effects of intravenous amiodarone on depolarization and repolarization: A case report
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Longitudinal analysis of the depressive effects of intravenous amiodarone on depolarization and repolarization: A case report
چکیده انگلیسی

SummaryIntravenous amiodarone (AMD) induces multiple antiarrhythmic effects via blocking of Na+, Ca2+, and IKr channels, and β receptors. A patient on chronic dialysis was administered AMD for nonsustained ventricular tachycardia after successful cardiopulmonary resuscitation. QT prolongation occurred 5 h after AMD administration. AMD was withdrawn at 24 h because of prolonged QTc interval (716 ms), which persisted for a further 48 h (661 ms). Ventricular premature contraction (VPC) was significantly decreased at 7 h; however, VPC increased again after discontinuing AMD. Depolarization changes induced by the Na+-channel blocking action of AMD were analyzed. There was increasing filtered QRS-duration and duration of low-amplitude signals at voltage <40 μV, and decreasing root-mean-square voltage of signals in the last 40 ms of ventricular late potentials (LPs) within 7 h. However after stopping AMD, LPs were reversed. The blood concentration of AMD reached the effective level within 10 min but decreased immediately to an ineffective level. Onset and disappearance of the VPC-inhibiting effect corresponded to the depressive effect on depolarization but not with the increase in the prolonged repolarization effect and blood concentration. Even if the QT interval is sufficiently prolonged, the Na+-channel blocking action is required for AMD to induce the antiarrhythmic effect.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Cardiology - Volume 54, Issue 3, December 2009, Pages 460–465
نویسندگان
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