کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2963749 | 1178573 | 2009 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Association of monocyte chemoattractant protein 1 gene polymorphism with susceptibility to nonfamilial idiopathic dilated cardiomyopathy Association of monocyte chemoattractant protein 1 gene polymorphism with susceptibility to nonfamilial idiopathic dilated cardiomyopathy](/preview/png/2963749.png)
SummaryBackgroundThe cytotoxic action of leukocytes is known to be a probable cause of the cardiac myocyte damage seen in idiopathic dilated cardiomyopathy (IDC). Monocyte chemoattractant protein 1 (MCP-1) contributes to enhanced leukocyte recruitment and activation resulting in chronic damage of cardiomyocytes. MCP-1 has been reported to be dynamically regulated in IDC and may contribute to the deterioration of left ventricular function. In addition, a polymorphism at −2518 (G/A) in the MCP-1 gene affects the level of MCP-1 expression in response to an inflammatory stimulus.Methods and resultsWe genotyped the polymorphism at −2518 G/A in the MCP-1 gene in 73 Japanese patients with nonfamilial IDC and 349 healthy controls. The distribution of the MCP-1 genotypes in the IDC patients differed significantly from the controls (p = 0.016). In a dominant G allele model, there was a significant difference in the distribution of genotypes between the two groups (p < 0.01). The odds ratio for nonfamilial IDC associated with the GG vs. non-GG genotype was 10.4 (95% CI = 1.7–64.5) after adjustment for the confounding factors.ConclusionsThese findings suggest that the G allele at −2518 in the MCP-1 gene may be a novel genetic marker of susceptibility to nonfamilial IDC.
Journal: Journal of Cardiology - Volume 54, Issue 1, August 2009, Pages 66–70