Influence of food intake on the QT and QT/RR relation

• Knowledge on meal induced QT interval changes is important in trials.
• Meal intake induced a significant heart rate increase.
• Adequate subject-specific and Fridericia QT correction remained unchanged.

BackgroundThere are conflicting data on the influence of meal intake on the QT interval.MethodsTen healthy subjects were studied before and after a standardized breakfast and lunch with a sequence of supine resting, standing and exercise. Data collection was performed using a 12-lead Holter with semi-automated analysis. QT correction was performed using Fridericia (QTcF) correction formula and a subject-specific method based on individual QT/RR-regression (QTcI).ResultsMeal intake induced significant changes in HR (p < 0.001), but not in QTcF (p = 0.512) or QTcI (p = 0.739). Postural analysis showed only significant differences in supine position for HR (p = 0.010), not when standing or during exercise.ConclusionFood intake induced an increase in heart rate limited to supine position. Using QTcF and QTcI no QTc changes were found.