کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2967807 1178858 2013 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
T wave alternans in experimental myocardial infarction: Time course and predictive value for the assessment of myocardial damage
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
T wave alternans in experimental myocardial infarction: Time course and predictive value for the assessment of myocardial damage
چکیده انگلیسی

BackgroundT-wave alternans (TWA) is associated with prognosis after myocardial infarction (MI), however its link to the extent of ischemic injury has not been clarified. We analyzed the course of TWA and its relation to myocardial damage in experimental myocardial infarction.MethodsIn 21 pigs, infarction was induced by 40-minute long balloon inflation in LAD under continuous 12-lead ECG monitoring. TWA was assessed in a 32-beat sliding window, using periodic component analysis and the Laplacian Likelihood Ratio method. Myocardium at risk (MaR) and infarct size (IS) were evaluated by SPECT and magnetic resonance imaging respectively.ResultsTWA appeared at 7.2 ± 4.5 minutes of occlusion, reached its maximum at 12.7 ± 6.3 and lasted until 26.5 ± 9.2 minutes. The maximal level of TWA was associated with both MaR (r = 0.499, p = 0.035) and IS (r = 0.65, p = 0.004).ConclusionTWA magnitude is associated with both MaR and IS in experiment, which encourages further studies in clinical settings.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Electrocardiology - Volume 46, Issue 3, May–June 2013, Pages 263–269
نویسندگان
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