Factors associated with development of prolonged QRS duration over 20 years in healthy young adults: the Coronary Artery Risk Development in Young Adults study

We found no long-term associations of modifiable risk factors with incident QRSd >100 milliseconds. Men, whites, and those with higher ECG-left ventricular mass index and QRSd in young adulthood are at an increased risk for incident prolonged QRSd by middle age.