Increase of ABCG2/BCRP+ side population stem cells in myocardium after ventricular unloading

SPC are increased significantly in the myocardium after ventricular unloading, suggesting a role for stem cell proliferation during “reverse cardiac remodeling.” These cells might proliferate and commit to different cell lineages, such as cardiomyocytes or endothelium, and thus ameliorate cardiac function.