کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2978431 1179527 2012 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Relationship between HLA molecules and late restenosis after coronary stent placement
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Relationship between HLA molecules and late restenosis after coronary stent placement
چکیده انگلیسی

ObjectiveThe objective of this study is to confirm whether there is relation between the human leucocyte antigen (HLA) locus and restenosis after percutaneous coronary intervention (PCI) holds in our patient population and whether it can be useful as a prognostic factor.MethodsWe examined the HLA phenotypes in 46 consecutive patients (39 men, 7 women, mean age of 57 ± 9 years) who had successful stent implantation in the coronary artery. Selective coronary arteriography was performed 6 months after coronary stenting to assess the presence of restenosis. The HLA phenotyping was performed for HLA-A,-B,-C antigens by Terasaki microlymphocytotoxicity technique and for HLA-DR alleles with PCR-SSP technique.ResultsRestenosis(R+) was present in 12 (26.1%) patients (11 men, 1 woman, mean age of 57 ± 10 years). For HLA Class I antigens frequency of HLA-B62 and HLA-CW2 antigen was slightly higher in restenotic patients but did not reach statistical significance. For HLA-DR alleles restenotic patients had higher frequencies for HLA-DRB1∗01(R+ %25, R− %14.7), and HLA-DR11(R+ %41.7, R− %20.6), without reaching statistical significance and lower frequencies for DR7(R+ %0, R− %17.6) and D13(R+%8.3, R− %32.4) and HLA-DR53 (R+ %25, R− %35.3) without reaching statistical significance.ConclusionIn conclusion, results show that there was no relationship between the development of restenosis and HLA-subtypes.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the Saudi Heart Association - Volume 24, Issue 2, April 2012, Pages 85–88
نویسندگان
, , , , , , ,