Labetalol, nebivolol, and propranolol relax human radial artery used as coronary bypass graft

We speculated that the relaxant effect of labetalol, nebivolol, and propranolol was due partly to the Ca2+-activated K+ channels. In addition, the relaxation induced by nebivolol was largely related with nitric oxide release. Nebivolol, and partly propranolol, may provide significant therapeutic benefit, but labetalol can be a good alternative for coronary artery bypass grafting with radial artery use.