دانلود مقالات ISI درباره Emax + ترجمه فارسی

تأثیر تجویز مجدد روی واکنش پذیری عضلات صاف در سه مدل انقباضی

Effect of reperfusion on vascular smooth muscle reactivity in three contraction models

Keywords: CRC; concentration response curve; EC50; half maximal effect concentration; Emax; maximal tissue response; mas-7; mastoparan-7; PLC; phospholipase C; PT; pertussis toxin; Ischemia; Reperfusion; Mastoparan-7; G-protein; Vascular smooth muscle;

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2019 سفارش ترجمه

بررسی اثر افسردگی قلبی عروقی برای پروپوفول در دوره القای بیهوشی در بیماران مبتلا به چاقی مفرط

Characterization of cardiovascular depression effect for propofol during anesthesia induction period on morbidly obese patients

Keywords: MO; morbid obesity; MAP; mean arterial blood pressure; SAP; systolic arterial blood pressure; DAP; diastolic arterial blood pressure; CO; cardiac output; PK; pharmacokinetic; PD; pharmacodynamics; TBW; total body weight; LBW; lean body weigh; ke0; the tra

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2018 سفارش ترجمه

شناسایی بقایای تثبیت شده حفظ شده برای فعالیت زیستی یک پپتید پدال / نوروپپتید نوع ارکوکینین

Identification of evolutionarily conserved residues required for the bioactivity of a pedal peptide/orcokinin-type neuropeptide

Keywords: SMP; starfish myorelaxant peptide; SAR; structure-activity relationships; PP; pedal peptide; OK; orcokinin; ACh; acetylcholine; TFA; trifluoroacetic acid; RP; reversed-phase; HOBT; 1-hydroxybenzotriazole; DIPCI; N,N-diisopropylcarbodimide; ASW; artificial

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2018 سفارش ترجمه

استفاده از دستگاه پلیمری مش برای بازسازی دستگاه شریان بطن چپ سمت چپ در منگنز ایسکمیک

Application of polymer-mesh device to remodel left ventricular-mitral valve apparatus in ischemic mitral regurgitation

Keywords: valvular disease; polymer; left ventricular remodeling; mitral regurgitation; coronary artery disease; 2D; 2-dimensional; 3D; 3-dimensional; dP/dt; rate of rise of left ventricular pressure; EDV; end-diastolic volume; Emax; slope of end-systolic pressureâ

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2018 سفارش ترجمه

3،4-دیامینوپیریدین فلج را در دیافراگم های مضر نوتروکسین بوتولینیوم از طریق دو مکانیسم متمایز عملکرد

3,4-diaminopyridine reverses paralysis in botulinum neurotoxin-intoxicated diaphragms through two functionally distinct mechanisms

Keywords: Botulinum neurotoxin; 3,4-Diaminopyridine; Isometric muscle contractions; Endplate recordings; Neurotransmission; Release probability; BoNT; botulinum neurotoxin; DAP; 3,4-diaminopyridine; HC; heavy chain; LC; light chain; NMJ; neuromuscular junction; EPP

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2018 سفارش ترجمه

ارزش الاستوگرافی موج برشی در پیش بینی متاستاز غدد لنفاوی ناحیه گردن ناشناخته در کارسینوم نازوفارنکس: یک مطالعه مقدماتی

The value of shear wave elastography in predicting for undiagnosed small cervical lymph node metastasis in nasopharyngeal carcinoma: A preliminary study

Keywords: NPC; nasopharyngeal carcinoma; CT; computed tomography; MRI; magnetic resonance imaging; US; ultrasonography; 18F-FDG; Fluorine 18 fluorodeoxyglucose; PET; positron emission tomography; SWE; shear wave elastography; sLN; small lymph node; S/L; the greates

دانلود رایگان متن کامل مقاله ISI 34 صفحه سال انتشار : 2018 سفارش ترجمه

جهش های ردوپسین اشتباه شده ویژگی های تجمع متغیر را نشان می دهند

Misfolded rhodopsin mutants display variable aggregation properties

Keywords: A:D; acceptor to donor; adRP; autosomal dominant retinitis pigmentosa; DAPI; 2-(4-amidinophenyl)-1H-indole-6-carboxamidine; DM; n-dodecyl-β-d-maltoside; DMSO; dimethyl sulfoxide; ER; endoplasmic reticulum; Emax; maximal FRET efficiency; FRET; Förster re

دانلود رایگان متن کامل مقاله ISI 43 صفحه سال انتشار : 2018 سفارش ترجمه

مقایسه فارماکولوژی بلوک کننده گیرنده اول کانابینوئید سنتی و غیر سنتی در مدل های جوندگان در داخل بدن

Pharmacological comparison of traditional and non-traditional cannabinoid receptor 1 blockers in rodent models in vivo

Keywords: CB1R; cannabinoid receptor 1; BW; body weight; DIO; diet-induced obesity; ED50; the dose where the predicted effect reaches 50%; Emax; the dose where the predicted effect reaches 100%; LED; least statistically effective dose; USV; ultrasonic vocalization;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2017 سفارش ترجمه

روشهای بررسی عملکرد بطری راست و اتصال بافتی-شریانی

Methods for Evaluating Right Ventricular Function and Ventricular-Arterial Coupling

Keywords: Right ventricular function; Pulmonary hypertension; Reserve; Ventricular-arterial coupling; AT; acceleration time; CI; cardiac index; CMR; cardiac magnetic resonance; CPET; cardiopulmonary exercise testing; CTEPH; chronic thromboembolic pulmonary hyperten

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2016 سفارش ترجمه

تجزیه کارآمد از انتظارات حداکثر برای توزیع نرمال و مرتبط چند متغیره

An efficient decomposition of the expectation of the maximum for the multivariate normal and related distributions

Keywords: C25, C61, C63; Expectation of the maximum; Emax; Multivariate normal; Monte Carlo integration; Dynamic structural models;

دانلود رایگان متن کامل مقاله ISI 45 صفحه سال انتشار : 2016 سفارش ترجمه

داروهای ریوی، گوارشی و تخمدان پپوفول محافظت در برابر هیپر واکنش اپیوئیدی عضله صاف در راه هوا در یک مدل اسب از بیهوشی تزریقی تحت کنترل هدف

Pulmonary, gastrointestinal and urogenital pharmacologyPropofol protects against opioid-induced hyperresponsiveness of airway smooth muscle in a horse model of target-controlled infusion anaesthesia

Keywords: ANOVA; analysis of variance; BHR; bronchial hyperresponsiveness; E; effect; EFS; electrical field stimulation; EC50; concentration inducing 50% Emax; Emax; maximal effect; iNOS; inducible nitric oxide synthase; NKA; neurokinin A; NKn receptor; neurokinin

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

هیستیدین 37.36 (305) در دامنه فعال سازی گیرنده پپتید محافظت شده از گونادوتروپین هورمون آزاد کننده گیرنده های گیرنده اتصال پپتید و فعال شدن گیرنده

Histidine7.36(305) in the conserved peptide receptor activation domain of the gonadotropin releasing hormone receptor couples peptide binding and receptor activation

Keywords: 2-Nal; 2-naphthylalanine; B0; radio-ligand bound in the absence of competing unlabeled ligand; DMEM; Dulbecco's modified Eagle's medium; FCS; fetal calf serum; GnRH; gonadotropin releasing hormone; GPCR; G protein-coupled receptor; IP; inositol phosphate;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2015 سفارش ترجمه

تعیین فارماکولوژی تعامل بین آکلییدینیم برمید و فومورات فرموترول بر روی برونکسی جدا شده از انسان

Pharmacological characterization of the interaction between aclidinium bromide and formoterol fumarate on human isolated bronchi

Keywords: β2-AR; β2-adrenoreceptor; ASM; airway smooth muscle; BI; Bliss independence; COPD; chronic obstructive pulmonary disease; CRC; concentration-response curve; E; effect; EFS; electrical field stimulation; ECn; effective concentration for n% of maximal eff

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

اثر افزایش داروی زا در پس آزمون بر روی چرخش بطن چپ و سویه در یک مدل خرگوش

Effect of Pharmacologic Increases in Afterload on Left Ventricular Rotation and Strain in a Rabbit Model

Keywords: Echocardiography; 2D-strain imaging; Cardiovascular function; Rotation; Ventricular-arterial coupling; Speckle-tracking; CO; Cardiac output; EA; Arterial elastance; Emax; Left ventricular end-systolic elastance; εCirc; Global circumferential strain; LV;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

Introduction of an extra tryptophan fluorophore by cataract-associating mutations destabilizes βB2-crystallin and promotes aggregation

Keywords: βB2-crystallin; Congenital hereditary cataract; Protein aggregation; Protein folding; Trp fluorophore; UV damage; ANS; 1-anilinonaphtalene-8-sulfonate; CD; circular dichroism; DTT; dithiothreitol; Emax; maximum emission wavelength of fluorescence; IPTG;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2018 سفارش ترجمه

Diagnostic performances of shear-wave elastography and B-mode ultrasound to differentiate benign and malignant breast lesions: the emphasis on the cutoff value of qualitative and quantitative parameters

Keywords: SWE; shear-wave elastography; US; ultrasound; Emax; max elasticity; Emean; mean elasticity; Eratio; elasticity ratio; SD; standard deviation; Breast ultrasound; Shear-wave elastography; Cutoff;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2018 سفارش ترجمه

Bioavailability and Cardiovascular Effects of Adrenaline Administered by Anapen Autoinjector in Healthy Volunteers

Keywords: Anapen; Autoinjectors; Adrenaline pharmacokinetics; Anaphylaxis; Cardiovascular responses; AUC; Area under the curve; BMI; Body mass index; Cmax; Maximum concentration; Emax; Maximum effect; HR; Heart rate; PK; Pharmacokinetic; SBP; Systolic blood pressur

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2018 سفارش ترجمه

The toxic effects of monosodium glutamate (MSG) - The involvement of nitric oxide, prostanoids and potassium channels in the reactivity of thoracic arteries in MSG-obese rats

Keywords: Monosodium glutamate; Nitric oxide; Obesity; Potassium channels; Thromboxane A2; A23187; calcium ionophore; BKCa; Large Conductance Ca2+-activated K+ channels; cGMP; cyclic guanosine monophosphate; COX; cyclooxygenase; EDCF; endothelial derived contractin

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2018 سفارش ترجمه

Preclinical assessment of utility of M6S for multimodal acute and chronic pain treatment in diabetic neuropathy

Keywords: δ-OR; delta-opioid receptor; DPN; diabetic polyneuropathy; ED50; half-effective drug dose; Emax; maximally effective drug dose; HPT; hot plate threshold; κ-OR; kappa opioid receptor; M6S; morphine-6-O-sulfate; MPE; maximum possible effect; μ-OR; mu-opi

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2018 سفارش ترجمه

Development of potent and proteolytically stable human neuromedin U receptor agonists

Keywords: Neuromedin U (NMU); NMU-8; Neuromedin U receptor agonists; Plasma stability; 1′Nal; 1′-naphtylalanine; 2′Nal; 2′-naphtylalanine; 7-OH-Tic; 7-hydroxy-L-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid; ACN; acetonitrile; AUC; area under the curve;

دانلود رایگان متن کامل مقاله ISI 30 صفحه سال انتشار : 2018 سفارش ترجمه

The cataract-causing mutation G75V promotes γS-crystallin aggregation by modifying and destabilizing the native structure

Keywords: ADCC; autosomal dominant congenital cataract; ANS; 1-anilinonaphtalene-8-sulfonate; BSA; bovine serum albumin; CD; circular dichroism; DTT; dithiothreitol; Emax; maximum emission wavelength of intrinsic Trp fluorescence; GdnHCl; guanidine hydrochloride; I

دانلود رایگان متن کامل مقاله ISI 31 صفحه سال انتشار : 2018 سفارش ترجمه

The long-term effect of maternal dietary protein restriction on 5-HT1A receptor function and behavioral responses to stress in adulthood

Keywords: 5-HT; serotonin; PND; postnatal day; ED50; dose of drug that is pharmacologically effective for 50% of the population; Emax; concentration that produces the maximum possible response for that agonist; 8-OH-DPAT; 8-Hydroxy-2-(dipropylamino)tetralin hydrobr

دانلود رایگان متن کامل مقاله ISI 34 صفحه سال انتشار : 2018 سفارش ترجمه

Antihypertensive responses of vasoactive androgens in an in vivo experimental model of preeclampsia

Keywords: DHEA; dehydroepiandrosterone; TES; testosterone; 5α-DHT; 5α-dihydrotestosterone; 5β-DHT; 5β-dihydrotestosterone; BP; blood pressure; PT; treated pregnant; NP; normal pregnant; HR; heart rate; MAP; mean arterial blood pressure; Phe; phenylephrine; AR;

دانلود رایگان متن کامل مقاله ISI 35 صفحه سال انتشار : 2018 سفارش ترجمه

Pharmacokinetic-pharmacodynamic modeling to study the anti-dysmenorrhea effect of Guizhi Fuling capsule on primary dysmenorrhea rats

Keywords: Guizhi Fuling capsule; Primary dysmenorrhea; Pharmacokinetic-pharmacodynamic model; Anti-dysmenorrhea effect; Ratios of PGE2/PGF2α and 6-Keto-PGF1α/TXB2; ALB; albiflorin; AMY; amygdalin; ARA; arachidonic acid; AUC0-t; area under the time-concentration

دانلود رایگان متن کامل مقاله ISI 39 صفحه سال انتشار : 2018 سفارش ترجمه

Impact of type 2 diabetes on vascular reactivity to cGMP generators in human internal thoracic arteries

Keywords: ANOVA; analysis of variance; CABG; coronary artery bypass grafting; Emax; maximal response; HbA1c; glycated hemoglobin; NO; nitric oxide; pD2; negative logarithm of the dilator concentration that produces one-half Emax; RNS; reactive nitrogen species; ROS

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2017 سفارش ترجمه

Characterization and structure-activity relationship of natural flavonoids as hERG K+ channel modulators

Keywords: HEK293 cells; human embryonic kidney 293 cells; hERG; human ether-à-go-go-related gene; IC50; 50% inhibiting concentration; Emax; maximum efficacy; Flavonoids; Quercetin; Fisetin; hERG currents;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

Concurrent bullatine A enhances morphine antinociception and inhibits morphine antinociceptive tolerance by indirect activation of spinal κ-opioid receptors

Keywords: ANOVA; analysis of variance; CFA; complete Freund's adjuvant; ED50; half-effective dose; Emax; maximum effect; GNTI; 5'-guanidinonaltrindole; HPLC; high performance liquid chromatography; LPS; lipopolysaccharides; NMDA; N-methyl-D-aspartate; STZ; strept

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

In Vitro-In Vivo Extrapolation of Metabolism- and Transporter-Mediated Drug-Drug Interactions-Overview of Basic Prediction Methods

Keywords: drug interaction; cytochrome P450s; membrane transport/transporters; regulatory; guidance/guideline; ADME; absorption, distribution, metabolism and excretion; BCRP; breast cancer resistance protein; CYP; cytochrome P-450; d; induction calibration factor;

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2017 سفارش ترجمه

Exosome is a mechanism of intercellular drug transfer: Application of quantitative pharmacology

Keywords: Exosome; Exocytosis; Intercellular drug transfer; Quantitative pharmacology; Chemoresistance; AChE; acetylcholinesterase; Conditioned Medium; culture medium collected after incubating cells under preselected conditions; CV; coefficient of variation; Cytot

دانلود رایگان متن کامل مقاله ISI 34 صفحه سال انتشار : 2017 سفارش ترجمه

Pharmacological preclinical characterization of LAS190792, a novel inhaled bifunctional muscarinic receptor antagonist /β2-adrenoceptor agonist (MABA) molecule

Keywords: COPD; Bronchodilator; Long-acting β2-adrenoceptor agonist; Long-acting muscarinic antagonist; ACh; acetylcholine; ANOVA; analysis of variance; β; beta-adrenoceptor; cAMP; cyclic adenosine monophosphate; CHO; Chinese hamster ovary; CI; confidence interva

دانلود رایگان متن کامل مقاله ISI 40 صفحه سال انتشار : 2017 سفارش ترجمه

Synthesis and binding characteristics of [3H]neuromedin N, a NTS2 receptor ligand

Keywords: BH; Bolton-Hunter; Bmax; maximal number of the binding sites; BSA; bovine serum albumin; DIPEA; N,N-diisopropylethylamine; DMF; N,N-dimethylformamide; EC50; half maximal effective concentration; Emax; maximal stimulation (Efficacy); GDP; guanosine 5′-

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2016 سفارش ترجمه

l-Cys/CSE/H2S pathway modulates mouse uterus motility and sildenafil effect

Keywords: Sildenafil; l-Cysteine; Sodium hydrogen sulfide; PDE5; phosphodiesterase type 5; H2S; hydrogen sulfide; l-Cys; l-Cysteine; CBS; cystathionine-β-synthase; CSE; cystathionine-γ-lyase; PAG; DL-propargilglycine; AOAA; aminooxiacetic acid; Emax; maximum effe

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

Anisotropy of Solid Breast Lesions in 2D Shear Wave Elastography is an Indicator of Malignancy

Keywords: Elastography; Breast; Breast cancer; Ultrasound; Shear wave elastography; AD; anisotropic difference (difference of the measurements in each plane); AF; anisotropy factor (square of AD); AUC; area under the curve (statistic measurement to evaluate the dia

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

New insights on pyrimidine signalling within the arterial vasculature - Different roles for P2Y2 and P2Y6 receptors in large and small coronary arteries of the mouse

Keywords: Coronary circulation; Knock-out mice; Purinergic receptors; P2Y2; P2Y6; ATP; adenosine triphosphate; ATPγS; adenosine-5′-O-(3-thiotriphosphate); EC50; 50% of the maximum response; ENTPDase; ectonucleoside triphosphate diphosphohydrolase; ET-1; endothel

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2016 سفارش ترجمه

Methylglyoxal mediates streptozotocin-induced diabetic neuropathic pain via activation of the peripheral TRPA1 and Nav1.8 channels

Keywords: Methylglyoxal; Diabetic neuropathic pain; TRPA1; Nav1.8; Methylglyoxal scavengers; AGE; advanced glycation end-product; TRPA1; transient receptor potential channel ankyrin 1; AMPK; AMP-activated protein kinase; DMSO; dimethyl sulfoxide; PEG400; polyethyle

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2016 سفارش ترجمه

Labetalol, nebivolol, and propranolol relax human radial artery used as coronary bypass graft

Keywords: 16; 23; CABG; coronary artery bypass grafting; Emax; maximum relaxant effect; L-NAME; NG-nitro-L-arginine methyl ester; NO; nitric oxide; RA; radial artery; TEA; tetraethyl ammonium;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2015 سفارش ترجمه

Fsn0503h antibody-mediated blockade of cathepsin S as a potential therapeutic strategy for the treatment of solid tumors

Keywords: Cathepsin S; Fsn0503h antibody; Cathepsin S blockade; Cell invasiveness; Colo-205 xenografts; ADCC; antibody-dependent cellular cytotoxicity; ANOVA; analysis of variance; Cat-S; cathepsin S; DMSO; dimethyl sulfoxide; ECM; extracellular matrix; Emax; maxim

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

Association of Myocardial T1-Mapping CMR With Hemodynamics and RV Performance in Pulmonary Hypertension

Keywords: equilibrium contrast; extracellular volume; magnetic resonance; native T1; pulmonary hypertension; T1 mapping; CMR; cardiac magnetic resonance; Ea; effective elastance; Emax; maximal end-systolic elastance; Eq-ECV; equilibrium contrast extracellular vol

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

Arylpiperazine agonists of the serotonin 5-HT1A receptor preferentially activate cAMP signaling versus recruitment of β-arrestin-2

Keywords: 5-HT; 5-hydroxytryptamine; cAMP; 3′,5′-cyclic adenosine monophosphate; ERK1/2; extracellular signal-regulated kinases 1/2; GPCR; G protein-coupled receptor; LogEC50; logarithm of agonist concentration that induces half-maximal response; Emax; maximal

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

Dunaliella salina Hsp90 is halotolerant

Keywords: ANS; 1-anilinonaphtalene-8-sulfonate; CD; circular dichroism; Emax; emission maximum wavelength of the intrinsic fluorescence; IPTG; isopropyl-1-thio-β-d-galactopyranoside; MW; molecular weight; PAGE; polyacrylamide gel electrophoresis; SEC; size-exclusi

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

Effects of the I682F mutation on JAK2's activity, structure and stability

Keywords: JAK; Janus kinase; JH; JAK homology; STAT5s; ignal transducer and activator of transcription 5; B-ALL; B-cell acute lymphoblastic leukemia; MPDs; myeloproliferative disorders; ALL; acute lymphoblastic leukemia; WT; Wild type; ANS; 1-anilino-8-naphthalenes

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

Cardiovascular pharmacologyPannexin-1 channels do not regulate α1-adrenoceptor-mediated vasoconstriction in resistance arteries

Keywords: Emax; maximum possible effect for the agonist; KPSS; isotonic potassium physiological salt solution; L-NAME; Nω-nitro-l-arginine methyl ester hydrochloride; NO; nitric oxide; NOS; nitric oxide synthase; PSS; physiological salt solution; Px1; pannexin-1;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

Comparative study of the effect of PTH (1-84) and strontium ranelate in an experimental model of atrophic nonunion

Keywords: OP; osteoporosis; PTH; parathyroid hormone; SrR; strontium ranelate; Fmax; maximum force; Emax; maximum energy; OS; substraction osteotomy; Fracture gap; Experimental pseudoartrosis; Atrophic nonunion bone repair; Human PTH 1-84 (PTH 1-84); Strontium

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

Endomorphin-1 analogues (MELs) penetrate the blood-brain barrier and exhibit good analgesic effects with minimal side effects

Keywords: Antinociception; Blood-brain barrier; Constipation; Endomorphin; Tolerance; BBB; blood−brain barrier; cAMP; cyclic adenosine monophosphate; CCI; chronic constriction injury; CNS; central nervous system; DOR; δ opioid receptor; EM-1; endomorphin-1; EM

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

Deletion of protein tyrosine phosphatase 1b in proopiomelanocortin neurons reduces neurogenic control of blood pressure and protects mice from leptin- and sympatho-mediated hypertension

Keywords: 5HT; 5-hydroxytryptamine; ACh; acetylcholine; BP; blood pressure; DBP; diastolic blood pressure; Emax; maximum possible effect; Jak-2; janus kinase-2; l-NAME; N-nitro-l-arginine methyl ester; MAP; mean arterial pressure; NOS; nitric oxide synthase; Phe; p

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

Structure-kinetics relationships of Capadenoson derivatives as adenosine A1 receptor agonists

Keywords: Residence time; Structure-affinity relationships; Structure-kinetics relationships; Adenosine A1 receptor; Extracellular loops; ADA; adenosine deaminase; Ac; acetyl; BCA; bicinchoninic acid; BEDROC; Boltzmann-enhanced discrimination of receiver-operating

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2015 سفارش ترجمه

Calcium-permeable AMPA receptors trigger vesicular glutamate release from Bergmann gliosomes

Keywords: Cerebellum; Gliosomes; Gliotransmitter release; GluA2-lacking AMPA receptor; Neuroglia; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazole propionate; BLBP; brain specific lipid binding protein; [Ca2+]i; intragliosomal calcium concentration; CNQX; 6-cyano-7-ni

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2015 سفارش ترجمه

Anti-IL-23A mAb BI 655066 for treatment of moderate-to-severe psoriasis: Safety, efficacy, pharmacokinetics, and biomarker results of a single-rising-dose, randomized, double-blind, placebo-controlled trial

Keywords: IL-23A; mAb; psoriasis; pharmacokinetics; biomarkers; single dose; randomized; AE; Adverse event; AUEC; Area under the effect curve; DC-LAMP; Dendritic cell lysosome-associated membrane glycoprotein; Emax; Maximum effect; FC; Fold change; MACE; Major adve

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2015 سفارش ترجمه

Cataract-linked mutation R188H promotes βB2-crystallin aggregation and fibrillization during acid denaturation

Keywords: ANS; 1-anilinonaphtalene-8-sulfonate; BSA; bovine serum albumin; CD; circular dichroism; DTT; dithiothreitol; EM; electron microscope; Emax; maximum emission wavelength of intrinsic Trp fluorescence; IPTG; isopropyl-1-thio-β-d-galactopyranoside; SEC; siz

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2014 سفارش ترجمه

Sphingosine-1-phosphate (S1P) displays sustained S1P1 receptor agonism and signaling through S1P lyase-dependent receptor recycling

Keywords: BSA; bovine serum albumin; CHO; Chinese hamster ovary; CRC; concentration-response curve; EC50; half maximimal excitatory concentration; Emax; maximal efficacy versus a defined control; FBS; fetal bovine serum; GPCR; G protein coupled receptor; GRK; GPC

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2014 سفارش ترجمه