کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5827721 | 1558936 | 2014 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Pharmacological characterization of the interaction between aclidinium bromide and formoterol fumarate on human isolated bronchi
ترجمه فارسی عنوان
تعیین فارماکولوژی تعامل بین آکلییدینیم برمید و فومورات فرموترول بر روی برونکسی جدا شده از انسان
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کلمات کلیدی
FEV1β2-ARLong-acting β2-adrenoceptor agonistpEC50Krebs-Henseleithuman bronchiASMEmaxβ2-adrenoreceptorEFsECNPCLSformoterol fumarate - Formoterol FumarateLAMA - OLDAclidinium bromide - آکیدیینیم برومیدEffect - اثرmaximal effect - اثر حداکثرPrecision-cut lung slices - برش ریه دقتChronic obstructive pulmonary disease - بیماری مزمن انسدادی ریهCOPD - بیماری مزمن انسدادی ریهElectrical field stimulation - تحریک الکتریکی میدانsynergistic interaction - تعامل سینرژیکForced expiratory volume in 1 s - حجم انقباض اجباری در 1 ثانیهLABA - سودGlobal Initiative for Asthma - طرح جهانی برای آسمGlobal Initiative for Chronic Obstructive Lung Disease - طرح جهانی برای بیماری مزمن ریوی مزمنGold - طلاAirway smooth muscle - عضله صاف راه هواییConcentration-response curve - منحنی تمرکز-پاسخCRC - کد افزونگی دورهای GINA - گینا
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب سلولی و مولکولی
چکیده انگلیسی
Long-acting muscarinic receptor antagonists (LAMAs) and long-acting β2-adrenoceptor agonists (LABAs) cause airway smooth muscle (ASM) relaxation via different signal transduction pathways, but there are limited data concerning the interaction between these two drug classes on human bronchi. The aim of this study was to investigate the potential synergistic interaction between aclidinium bromide and formoterol fumarate on the relaxation of human ASM. We evaluated the influence of aclidinium bromide and formoterol fumarate on the contractile response induced by acetylcholine or electrical field stimulation (EFS) on human isolated airways (segmental bronchi and bronchioles). We analyzed the potential synergistic interaction between the compounds when administered in combination by using Bliss independence (BI) theory. Both aclidinium bromide and formoterol fumarate completely relaxed segmental bronchi pre-contracted with acetylcholine (Emax: 97.5±2.6% and 96.4±1.1%; pEC50 8.5±0.1 and 8.8±0.1; respectively). Formoterol fumarate, but not aclidinium bromide, abolished the contraction induced by acetylcholine in bronchioles (Emax: 68.1±4.5% and 99.0±5.6%; pEC50 7.9±0.3 and 8.4±0.3; respectively). The BI analysis indicated synergistic interaction at low concentrations in segmental bronchi (+18.4±2.7%; P<0.05 versus expected effect) and from low to high concentrations in bronchioles (+19.7±0.9%; P<0.05 versus expected effect). Low concentrations of both drugs produced a synergistic relaxant interaction on isolated bronchi stimulated with EFS that was sustained for 6 h post-treatment (+55.1±9.4%; P<0.05 versus expected effect). These results suggest that combining aclidinium bromide plus formoterol fumarate provides synergistic benefit on ASM relaxation of both medium and small human airways, which may have major implications for the use of this combination in the clinic.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmacology - Volume 745, 15 December 2014, Pages 135-143
Journal: European Journal of Pharmacology - Volume 745, 15 December 2014, Pages 135-143
نویسندگان
Mario Cazzola, Luigino Calzetta, Clive P. Page, Paola Rogliani, Francesco Facciolo, Amadeu Gavaldà , Maria Gabriella Matera,