کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2986596 1578687 2008 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A novel method to reduce pericardial adhesion: A combination technique with hyaluronic acid biocompatible membrane
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
A novel method to reduce pericardial adhesion: A combination technique with hyaluronic acid biocompatible membrane
چکیده انگلیسی

ObjectiveThis study was to evaluate the efficacy of the hyarulonic acid (HA) bioabsorbable membrane combined use with both expanded-polytetrafluoroethylene (ePTFE) and autologous pericardium for preventing postoperative pericardial adhesions.MethodsThe HA bioresorbable surgical membrane (Seprafilm, Genzyme, Cambridge, Mass) was used with either ePTFE or autologous pericardium in an experimental pericardial adhesion model. Twenty-four beagle dogs were classified as follows; Group A (n = 6): ePTFE only, Group B (n = 6): Seprafilm + ePTFE, Group C (n = 6): autologous pericardium only, Group D (n = 6): Seprafilm + autologous pericardium. Pericardial adhesions were evaluated at necropsy at 4, 8, and 12 weeks. The tenacity of adhesion was graded by macroscopic examination, and the adhesion tissue thickness was analyzed microscopically with an image processing program. The regeneration of mesothelial cells on neo-tissue fibrils were immunohistochemically studied.ResultsIn groups B and D, the adhesions were significant lower compared with those of control groups in the tenacity (Group A vs B: 2.5 ± 0.55 vs 1.5 ± 0.55, P < 0.05; Group C vs D: 3.2 ± 0.75 vs 0.33 ± 0.52, P < 0.01) and the tissue thickness (Group A vs B: 30.4 ± 12.9 vs 10.3 ± 4.42, P < 0.01; Group C vs D: 22.6 ± 11.5 vs 4.96 ± 4.87, P < 0.01). Immunohistochemically, a single layer of mesothelial cells were regenerated on the surface of neo-tissue fibrils in HA treated groups.ConclusionThe combined use of Seprafilm with either ePTFE or autologous pericardium effectively reduced the formation of pericardial adhesion.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The Journal of Thoracic and Cardiovascular Surgery - Volume 135, Issue 4, April 2008, Pages 850–856
نویسندگان
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