کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3001378 1180625 2015 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Leptin modulates nutrient reward via inhibitory galanin action on orexin neurons
ترجمه فارسی عنوان
لپتین پاداش مواد مغذی را از طریق اثر مهاری گالانین بر نورونهای اورکسین تعدیل می کند
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی سیستم های درون ریز و اتونومیک
چکیده انگلیسی


• GAL-LepRbKO shows ↓ galanin and ↓ GalR1 mRNA, ↑ body weight gain.
• GAL-LepRbKO shows ↑ orexin/hypocretin neuronal activation.
• GAL-LepRb neurons innervate local orexin/hypocretin and noradrenergic locus coeruleus neurons.
• Leptin regulates natural reward and body weight via GAL-LepRb neurons.

ObjectiveLeptin modulates food reward via central leptin receptor (LepRb) expressing neurons. Food reward requires stimulation of midbrain dopamine neurons and is modulated by central leptin action, but the exact central mechanisms remain unclear. Stimulatory and inhibitory leptin actions on dopamine neurons have been reported, e.g. by indirect actions on orexin neurons or via direct innervation of dopamine neurons in the ventral tegmental area.MethodsWe showed earlier that LepRb neurons in the lateral hypothalamus (LHA) co-express the inhibitory acting neuropeptide galanin (GAL-LepRb neurons). We studied the involvement of GAL-LepRb neurons to regulate nutrient reward in mice with selective LepRb deletion from galanin neurons (GAL-LepRbKO mice).ResultsWe found that the rewarding value and preference for sucrose over fat was increased in GAL-LepRbKO mice compared to controls. LHA GAL-LepRb neurons innervate orexin neurons, but not the VTA. Further, expression of galanin and its receptor GalR1 are decreased in the LHA of GAL-LepRbKO mice, resulting in increased activation of orexin neurons.ConclusionWe suggest galanin as an important mediator of leptin action to modulate nutrient reward by inhibiting orexin neurons.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular Metabolism - Volume 4, Issue 10, October 2015, Pages 706–717
نویسندگان
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