Blood free fatty acids were not increased in high-fat diet induced obese insulin-resistant animals

SummaryObjectiveThe close connection between high blood FFA and insulin resistance (IR) in obese individuals is well-known. The purpose of this study was to identify whether the blood FFA increased in obese-IR animals.MethodsObese-IR animal models were established using high-fat diet (HFD) or HFD and streptozocin, and treated with drugs.ResultsThe serum FFA of obese-IR animals was not increased, even significantly lower than that of normal animals, and were not significantly decreased when insulin sensitivity and obesity-related indices were ameliorated after treatment.ConclusionThe results suggest that blood FFA are unlikely the link between obesity and insulin resistance.