کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3003540 | 1180807 | 2013 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Xanthine derivatives as activators of alpha-amylase: Hypothesis on a link with the hyperglycemia induced by caffeine
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
کاردیولوژی و پزشکی قلب و عروق
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چکیده انگلیسی
SummaryInhibitors of the mammalian alpha-amylases have been widely studied as medicines to be used in diabetes and obesity. However, there are few reports on activation of the enzyme, which could be detrimental in those conditions. Here, the effect of purine-derivated compounds has been studied on porcine pancreatic alpha-amylase. Methylxanthine-derivatives pentoxyfilline, theobromine and caffeine caused a 20–30% increase in enzyme activity in the presence of the natural substrate, starch. The activation effect was not dose-dependent, observed in the range of 10–200 μM of the compounds, and hypothesized to be related with the hyperglycemia that is observed upon consuming caffeine.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Obesity Research & Clinical Practice - Volume 7, Issue 6, December 2013, Pages e487–e493
Journal: Obesity Research & Clinical Practice - Volume 7, Issue 6, December 2013, Pages e487–e493
نویسندگان
Elaheh Kashani-Amin, Parichehreh Yaghmaei, Bagher Larijani, Azadeh Ebrahim-Habibi,