کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3006959 | 1181022 | 2008 | 8 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Catecholaminergic Polymorphic Ventricular Tachycardia Catecholaminergic Polymorphic Ventricular Tachycardia](/preview/png/3006959.png)
Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a highly malignant form of arrhythmogenic disorder characterized by exercise- or emotional-induced polymorphic ventricular tachycardia in the absence of detectable structural heart disease. Because of the typical pattern of arrhythmias (bidirectional ventricular tachycardia and the occurrence and severity of arrhythmia correlated well with exercise workload) during exercise stress test, CPVT can be identified promptly. Molecular genetic screening of the genes encoding the cardiac ryanodine receptor and calsequestrin is critical to confirm uncertain diagnosis of CPVT. With the exception of β-blockers, no pharmacologic therapy of proven effectiveness is available: although β-blockers reduce the occurrence of ventricular tachycardia, 30% of patients treated with β-blockers still experience cardiac arrhythmias and eventually require implantable cardioverter defibrillator implantation to prevent cardiac arrest.
Journal: Progress in Cardiovascular Diseases - Volume 51, Issue 1, July–August 2008, Pages 23–30