کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3007361 1181353 2012 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
What we need to know about drug interactions in patients with pulmonary arterial hypertension
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
What we need to know about drug interactions in patients with pulmonary arterial hypertension
چکیده انگلیسی

In the past years, the number of selective vasodilatory drugs available for the management of patients with pulmonary arterial hypertension (PAH) has increased remarkably. Concomitant chronic or temporary treatment with warfarin, oral contraceptives, some antibiotics, statins or other drugs can exert potential significant drug–drug interactions to some of the specific vasodilatory drugs by competition, induction or inhibition of metabolic pathways. These drug interactions can adversely affect treatment efficacy by changes of their plasma levels and can cause potential harm. An example of a significant drug interaction is given in a case report. Combination therapy with specific pulmonary vasodilatory drugs is more and more the focus of clinical studies, as many patients fail to respond to monotherapy. Each of the substances could add positive treatment effects but they can also interact to each other by their metabolic pathways and increase side-effects or add synergistic effectiveness.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Progress in Pediatric Cardiology - Volume 34, Issue 2, December 2012, Pages 119–122
نویسندگان
, , ,