The implication of coronary artery malformations and congenital heart disease on cardiomyopathy

Coronary and congenital heart malformations contribute to and overlap with clinical cardiomyopathy. As cellular mechanisms and gene associations are better understood, overlap is becoming apparent between cardiomyopathies such as left ventricular non-compaction, hypertrophic cardiomyopathy and congenital heart disease. In current studies and registries, patients with clinical overlap are excluded limiting our understanding of the synergy of disease. We review contributing lesions and discuss genetic contributions to overlapping disease.