کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3007573 | 1181378 | 2006 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Maternal autoimmune disease and its impact on the fetal heart: Management and prognosis
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
کاردیولوژی و پزشکی قلب و عروق
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چکیده انگلیسی
Congenital complete atrioventricular heart block, myocarditis and endocardial fibroelastosis related to maternal anti-Ro and anti-La autoantibodies have been associated with a significant mortality, with most deaths occurring in utero or during infancy. Transplacental treatment with fluorinated steroids, in combination with β-mimetics at heart rates < 55 beats/min, has significantly improved the survival rate of affected patients in recent years. Severe fetal hyperthyroidism is a rare pregnancy condition that is induced by maternal thyroid stimulating antibodies. Persistent sinus tachycardia of > 160 beats/min is a clinical hallmark. Treatment with propylthiouracil and a β-blocker aims at inhibiting fetal thyroid hormone synthesis and controlling the fetal heart rate. Insulin-dependent maternal diabetes mellitus is associated with an increased incidence of cardiac malformations, including conotruncal lesions. Mild and reversible ventricular hypertrophy is common even in well-controlled maternal diabetes, without affecting the age-related changes in cardiac function.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Progress in Pediatric Cardiology - Volume 22, Issue 1, May 2006, Pages 85-93
Journal: Progress in Pediatric Cardiology - Volume 22, Issue 1, May 2006, Pages 85-93
نویسندگان
Edgar T. Jaeggi, Kevin S. Roman,