کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3010812 | 1181531 | 2007 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Terlipressin as an adjunct vasopressor in refractory hypotension after tricyclic antidepressant intoxication Terlipressin as an adjunct vasopressor in refractory hypotension after tricyclic antidepressant intoxication](/preview/png/3010812.png)
SummaryAim of study: To report the management of cardiovascular failure refractory to standard catecholamine therapy with terlipressin in a patient with tricyclic antidepressant (TCA) intoxication.Case report: A 41-year-old woman, with suicidal ingestion of 11.25 g amitriptyline and 1500 mg diclofenac, was admitted to the emergency department. After 30 min in ventricular fibrillation, with ongoing CPR, she regained a potentially perfusing rhythm, but with hypotension refractory to standard catecholamine therapy with adrenaline, 2 μg/kg/min (norepinephrine); adrenaline, 1 μg/kg/min (epinephrine) until 55 min after admission. An injection of 1 mg terlipressin restored mean arterial blood pressure >65 mmHg within 10 min. Ten hours after admission to the intensive care unit, catecholamine support could be withdrawn because of a stable haemodynamic state. Within 7 days, all organ function recovered, and the patient regained full neurological function.Conclusions: Successful management of cardiovascular failure with terlipressin after TCA intoxication refractory to catecholamines suggests a potential role for terlipressin as an adjunct vasopressor in severely hypotensive patients.
Journal: Resuscitation - Volume 72, Issue 2, February 2007, Pages 319–323