کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3014241 | 1181883 | 2010 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Aldosterona plasmática y filtrado glomerular en el paciente hipertenso con función renal conservada
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
کاردیولوژی و پزشکی قلب و عروق
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چکیده انگلیسی
There is increasing interest in the role of aldosterone in the pathophysiology of hypertension, cardiovascular disease and deteriorating renal function. The aim of this study was to investigate the relationship between aldosterone and the glomerular filtration rate (GFR) in hypertensive patients with preserved renal function. The study involved 186 consecutive hypertensive patients with a GFR >60 mL/min. The GFR was determined using the Modification of Diet in Renal Disease (MDRD) equation and the patients' plasma aldosterone levels were measured. Patients with a GFR between 60-89 mL/min had a significantly higher plasma aldosterone level than those with a GFR >90 mL/min (20.02 ng/dL vs. 15.3 ng/ dL; P<.05). Multivariate analysis showed that the plasma aldosterone level was independently associated with the GFR (B=-7.36; P<.001). In hypertensive patients with preserved kidney function, the plasma aldosterone level was observed to increase as the GFR decreased.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Revista Española de CardiologÃa - Volume 63, Issue 1, January 2010, Pages 103-106
Journal: Revista Española de CardiologÃa - Volume 63, Issue 1, January 2010, Pages 103-106
نویسندگان
Julián Roldán, Pedro Morillas, Jesús Castillo, Helder Andrade, Silvia Guillén, Daniel Núñez, Juan Quiles, Vicente Bertomeu,