Mecanismo de acción de los fármacos antitrombóticos

Since acute coronary syndrome results from coronary thrombosis, antiplatelet and anticoagulant drugs play a fundamental role in its treatment. Moreover, percutaneous coronary intervention, the preferred form of treatment in a large percentage of patients with this syndrome, is also a potent stimulator of platelet activation and blood coagulation. In this article, the mechanisms of platelet adhesion and aggregation and of blood coagulation are reviewed briefly. In addition, there is also a review of the antithrombotic drugs used in percutaneous coronary intervention, which includes their mechanisms of action, dosages, indications, and side-effects in patients with both stable and unstable coronary artery disease.