| کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
|---|---|---|---|---|
| 3026802 | 1182922 | 2016 | 4 صفحه PDF | دانلود رایگان |
کلید واژه ها
مقدمه
بهبود دارورسانی موضعی جهت مدیریت خونریزی
ذرات خود هدایت شونده می توانند محموله ها را از طریق مایعات بدن و خون انتقال دهند
دارو رسانی این ویوو با استفاده از ذرات خودهدایت شونده
بند آمدن خون با ذرات خود هدایت شونده
کابردهای بالقوه ی مکانیسم های رسانش پیشرفته در درمان خونریزی
شکل 1- توسعه ی دارورسانی موضعی به قسمت های زخمی بدن احتمال حیات را در طی خونریزی افزایش می دهد
Approaches to locally deliver drugs to specific regions of the body are being developed for many clinical applications, including treating hemorrhage. Increasing the concentration of therapeutic coagulants in areas where clots are forming and growing can be achieved by directing them to the injury, such as with catheters or external delivery devices, or by systemically administering therapeutics that target molecular signals of vascular damage. Treating severe hemorrhage by external measures is challenging because blood flow pushes hemostatic agents outward, reducing their efficacy. This review explains that self-propelling particles may be used for delivering therapeutics, such as coagulation factors, small molecules, or other chemical or biological agents, deep into wounds during hemorrhage. A recent example of self-propelling particles is highlighted, where propulsion enhanced the efficacy of a formulation of thrombin and tranexamic acid in treating bleeding in two murine models of hemorrhage and a porcine model of fatal, non-compressible hemorrhage. Many agents exist which modulate clotting, and novel approaches that facilitate their safe delivery to sites of vascular injury could reduce the enormous number of deaths from hemorrhage that occur globally.
Journal: Thrombosis Research - Volume 141, Supplement 2, May 2016, Pages S36–S39