کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3026887 | 1579198 | 2016 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Progestin isoforms provide different levels of protein S expression in HepG2 cells
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Progestin isoforms provide different levels of protein S expression in HepG2 cells Progestin isoforms provide different levels of protein S expression in HepG2 cells](/preview/png/3026887.png)
چکیده انگلیسی
In the presence of progestins, PS mRNA and protein expressions were significantly upregulated in HepG2 cells due to the augmentation of de novo PS mRNA expression modulated by RNA polymerase II (Pol II), thereby facilitating PS transcription elongation. Moreover, the transcription elongation inhibitor blocked progestin-mediated de novo PS mRNA expression. Conversely, progestin did not affect PROS1 promoter activity and PS mRNA stability. Pol II elongation efficiency in the newer-generation progestin (DRSP) treatment was not as strong compared with older-generation progestin (LNG), suggesting the difference in VTE risk between COC generations.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Thrombosis Research - Volume 145, September 2016, Pages 40-45
Journal: Thrombosis Research - Volume 145, September 2016, Pages 40-45
نویسندگان
Toshihiro Kozuka, Shogo Tamura, Nami Kawamura, Yukiko Nakata, Ryo Hasebe, Ayumi Makiyama, Yuki Takagi, Moe Murata, Naoki Mizutani, Akira Takagi, Tetsuhito Kojima,