Arguments favoring low versus high dose aspirin in the prophylaxis of venous thromboembolism

• Review of prospective RCT's on aspirin for venous thromboembolism (VTE)
• Aspirin at 80–250 mg/day reduces relative risk on VTE after orthopedic surgery.
• Aspirin doses 600–1300 mg/day or 2000–3000 mg/day seem less effective or worse.
• Such high aspirin doses block endogenous platelet inhibition (by e.g. PGI2).