کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3027588 | 1182981 | 2012 | 4 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Higher soluble P-selectin is associated with chronic venous insufficiency: The San Diego Population Study Higher soluble P-selectin is associated with chronic venous insufficiency: The San Diego Population Study](/preview/png/3027588.png)
IntroductionP-selectin is a cell adhesion molecule shown to play a role in venous thromboembolism. We evaluated whether higher P-selectin is associated with chronic venous insufficiency (CVI).Materials and MethodsIn a cohort of 2408 participants, the San Diego Population Study, peripheral venous disease was established by symptoms, clinical examination, and ultrasound. We measured P-selectin in a subsample of 352 CVI cases frequency matched to controls. Cases included four hierarchical groups of increasing severity of CVI.ResultsThe association of P-selectin with CVI considering all cases was weak, with an age, race and sex-adjusted odds ratio (OR) of 1.3 (95% CI 1.0-2.2) for values in the 3rd versus 1st tertile. The OR for cases in the two most severe groups was 2.3 (95% CI 1.2-4.2). Addition of body mass index to the model reduced this OR to 1.9 (95% CI 1.0-3.6).ConclusionsHigher circulating P-selectin was associated with more severe CVI, but not CVI overall. Results support that platelet and endothelial cell activation may be involved in the pathogenesis of CVI.
Journal: Thrombosis Research - Volume 130, Issue 5, November 2012, Pages 716–719