کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3027620 1182982 2011 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Pathogen sensing, subsequent signalling, and signalosome in human platelets
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Pathogen sensing, subsequent signalling, and signalosome in human platelets
چکیده انگلیسی

Beyond haemostasis, platelets exert a potent role in innate immunity and particularly in its inflammatory arm. The extent of this action remains however debatable, despite clear – and old – evidence of a link between platelets and infection. Platelets can sense infectious pathogens by pathogen recognition receptors and they can even discriminate between various types of infectious signatures. In reply, they can shape their capacity to respond by activating a signalosome and by producing different profiles of pro-inflammatory cytokines and related products. The links between pathogen sensing, signalosome activation and protein production, and their finely tuned regulation are still under investigation since platelets lack a nucleus and thus, canonical molecular biology and genomics apparati.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Thrombosis Research - Volume 127, Issue 4, April 2011, Pages 283–286
نویسندگان
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