کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3028432 | 1183012 | 2009 | 4 صفحه PDF | دانلود رایگان |
Obesity is associated with a high risk of cardiovascular events. Several haemostatic disturbances which could contribute to this increased risk have been described in obesity; nevertheless, the state of coagulation inhibitors has been scarcely studied in these patients. The aim of the present study was to compare activated protein C levels in obese patients and in a control group, and to evaluate the effect of weight loss. In 67 severe or morbid obese patients, an evaluation was performed at baseline and 3 months after diet. The same determinations were performed in 67 healthy volunteers with normal body weight. We also quantified the levels of protein C and prothrombin fragment 1 + 2. Obese patients showed significantly higher levels of activated protein C, protein C and fragment 1 + 2. No correlation was found between activated protein C and fragment 1 + 2 levels in obese patients. After three months of diet, a significant decrease in activated protein C and fragment 1 + 2 was observed. In conclusion, activated protein C levels are increased in obese patients, but only a minor fraction of this increase may be explained by the higher thrombin generation and C protein levels. Activated protein C levels decrease with weight loss, due in part to a thrombin generation reduction.
Journal: Thrombosis Research - Volume 123, Issue 5, March 2009, Pages 697–700