کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3029195 1183050 2010 14 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A Series of Natural Flavonoids as Thrombin Inhibitors: Structure-activity relationships
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
A Series of Natural Flavonoids as Thrombin Inhibitors: Structure-activity relationships
چکیده انگلیسی

A series of natural flavonoids has been evaluated as potential inhibitors of thrombin using the optimized method of thrombin time. Myricetin and quercetin have shown to be the best thrombin inhibitors tested. In order to investigate the thrombin recognition of the most active and selective compounds, a molecular modeling study has been performed using available Protein Data Bank (PDB) structures as receptor models for docking experiments. Structure-activity relationships of flavonoids (SARs) on thrombin would facilitate the design of chemical compounds with higher potency to serve as potential thrombin inhibitors, and provide information for the exploitation and utilization of flavonoids as thrombin inhibitors for thrombotic disease treatment.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Thrombosis Research - Volume 126, Issue 5, November 2010, Pages e365–e378
نویسندگان
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