کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3029334 1183063 2009 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Cancer-associated thrombosis: risk factors, candidate biomarkers and a risk model
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Cancer-associated thrombosis: risk factors, candidate biomarkers and a risk model
چکیده انگلیسی

Cancer and its treatments are well-recognized risk factors for venous thrombo-embolism (VTE). Although solid tumors have historically been associated with VTE, more recent data suggest similar risk in patients with hematologic malignancies as well. The risk of VTE is not equal for all cancer patients or even in the same patient over time. In addition to well-known risk factors such as tumor site, stage, chemotherapy and comorbidities, candidate biomarkers have recently been identified including platelet and leukocyte counts, tissue factor and P-selectin. A validated risk model incorporating some of these risk factors and biomarkers has been shown to be predictive of VTE in cancer. VTE is associated with mortality, morbidity, potential delay in treatments for cancer and consumption of scarce health-care resources. Hence, reducing VTE with targeted prophylaxis could improve outcomes for cancer patients.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Thrombosis Research - Volume 123, Supplement 4, 2009, Pages S18-S21