کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3029613 1183096 2008 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Factor VIIa binding to endothelial cell protein C receptor
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Factor VIIa binding to endothelial cell protein C receptor
چکیده انگلیسی

Recent studies have shown that factor VIIa (FVIIa) binds specifically to endothelial protein C receptor (EPCR), a known cellular receptor for protein C and activated protein C, on the endothelium. The formation of FVIIa:EPCR complexes neither supports the activation of coagulation nor modulates tissue factor-initiated coagulation. However, FVIIa interaction with EPCR, particularly at pharmacological concentrations of FVIIa, may impair EPCR-dependent protein C activation and activated protein C-mediated cell signaling by competing directly with them for binding to EPCR. FVIIa binding to EPCR may also contribute to FVIIa clearance. This review summarizes recent data on FVIIa interaction with EPCR and discusses potential physiological significance and consequences of the interaction.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Thrombosis Research - Volume 122, Supplement 1, 2008, Pages S3-S6