کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3029616 1183096 2008 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Role of tissue factor disulfides and lipid rafts in signaling
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Role of tissue factor disulfides and lipid rafts in signaling
چکیده انگلیسی

Tissue factor (TF) is a cellular receptor for coagulation factor VIIa (FVIIa), and the assembly of TF:FVIIa complexes on cell surfaces not only triggers the coagulation cascade but also transduces cell signaling via activation of protease-activated receptors. This brief review summarizes recent controversial data on the importance of protein disulfide isomerase-mediated disulfide bond switching in extracellular domain of TF in regulating its coagulant and cell-signaling activities. The review also discusses the importance of TF localization in lipid rafts and caveolae in maintaining its coagulant and signaling functions.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Thrombosis Research - Volume 122, Supplement 1, 2008, Pages S14-S18