کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3029874 1183118 2008 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Relevance of hemostasis on restenosis in clinically stable patients undergoing elective PTCA
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Relevance of hemostasis on restenosis in clinically stable patients undergoing elective PTCA
چکیده انگلیسی

BackgroundSecondary coronary thrombus formation is considered to be co-factor in the pathogenesis of restenosis after percutaneous transluminal coronary angioplasty (PTCA). Therefore systemic factors indicating a hypercoagulable disease state may be relevant for the process of coronary renarrowing. Even though experimental data suggest that in particular thrombin may be of major relevance for restenosis induced by mechanical injury, only little clinical data has been presented so far.Methods and resultsIn 60 consecutive patients, who had been clinical stable for at least 2 months, and who underwent elective and primarily successful PTCA, follow-up films were evaluated by means of quantitative coronary angiography in respect to a categorical and a continuous definition of restenosis, luminal narrowing > 50% and late luminal loss respectively. Of the chosen laboratory variables prothrombin fragment 1 + 2 (1.3 ± 0.5 vs. 0.9 ± 0.4 mmol/l, p < 0.001) red blood cell aggregation at low shear stress (13.5 ± 2.9 vs. 11.6 ± 2.8 units, p < 0.05), and plasminogen-activator inhibitor (3.7 ± 1.8 vs. 5.3 ± 3.2 U/ml p < 0.05) differentiated between patients with (n = 18) and without restenosis (n = 42). Late luminal loss correlated positively with prothrombin fragment 1 + 2 (r = 0.41, p < 0.001), plasminogen-activator inhibitor (r = − 0.28, p < 0.05) and plasmin–α2-antiplasmin complex (r = 0.39, p < 0.01).ConclusionsA hypercoagulable disease state and in particular thrombin generation characterize a high-risk group prone for restenosis in clinically stable oronary arterydisease.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Thrombosis Research - Volume 122, Issue 2, 2008, Pages 229–236
نویسندگان
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