The fibrinogen − 148 C/T polymorphism influences inflammatory response in experimental endotoxemia in vivo

Our findings indicate, that the common − 148 C/T polymorphism is associated with differences in the TNFα release in response to systemic LPS infusion in humans, and add to current evidence that gene-sequence changes in beta-fibrinogen locus can alter the ability of the host to respond to endotoxin.